Does Creatine Lead to Constipation? Creatine is a popular nutritional supplement used by athletes and bodybuilders to increase muscle mass mass. Even though it's been established to be helpful in encouraging people build strength, there are some likely Uncomfortable side effects which were linked with creatine use, which include constipation. https://wellnessprosper.com/does-creatine-cause-constipation-exploring-the-potential-link/