Decisions regarding the Zeiteinteilung of any elective procedures requiring anesthesia should take into consideration the benefits of the procedure weighed against the potential risks. PRECAUTIONS pentobarbital will decrease the level or effect of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Strong or moderate CYP3A ind... https://garrisonl553ync0.national-wiki.com/user