The interfacial residues are very conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal the kinase domains dimerize when PKR binds to activating dsRNAs19. https://aliciaxfqc223540.wikihearsay.com/2876730/new_step_by_step_map_for_pkrrating