If a mother or father with the proband is known to possess the pathogenic variant determined in the proband, the danger to your sibs of inheriting the pathogenic variant is fifty%. Because of lowered penetrance, sibs who inherit the pathogenic variant may or may not acquire aHUS (see Penetrance). Modifiers https://ahu-hire49269.humor-blog.com/31369691/the-ultimate-guide-to-ahu-s