Opioid activity is because of both equally low affinity binding on the mother or father compound and better affinity binding with the O-demethylated metabolite M1 to µ-opioid receptors. In animal models, M1 is up to 6 times additional powerful than tramadol in creating analgesia and 200 periods additional strong in https://francisk530lrw6.homewikia.com/user