Pentobarbital will lessen the level or outcome of conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. pentobarbital will decrease the extent or effect of meloxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Mysterious. Caution when discontinuing CYP3A4 inducers which are coadministered with hydrocodone; ... https://johnm686pni6.ktwiki.com/user